Therapeutic Effects of Fermented and Dried Corn Silk (Zea mays L.) on Induced Hyperuricemia and Hepatic Cell Injury in Wrister Rats

Maryam Mehmood; Beenish Israr

doi:10.64229/asdx9c50

Authors

Maryam Mehmood Institute of Home Sciences, Faculty of Food Nutrition and Home Sciences, University of Agriculture, Faisalabad, 38000, Pakistan Author
Beenish Israr Institute of Home Sciences, Faculty of Food Nutrition and Home Sciences, University of Agriculture, Faisalabad, 38000, Pakistan Author

DOI:

https://doi.org/10.64229/asdx9c50

Keywords:

Corn Silk, Creatinine, Hyperuricemia, Fermentation, Hepatocytic Injury

Abstract

A rare investigation has been made into the prevailing Hyperuricemia rate in developing countries. In Hyperuricemia (inclined serum uric acid) monosodium urate crystals deposit in joints and tissues. The goal of this research was to access the therapeutic effects of fermented corn silk tea and corn silk powder on hyperuricemia and their action to reduce hepatotoxicity in vivo, 80% ethanol extraction of fermented corn silk alleviated serum uric acid levels in an induced hyperuricemia Wrister rat model by Gentamycin. The efficacy study was for 45 days, containing 30 animals (male and female rats) divided into 6 groups (5 Wister rats in each group) with an average weight of 180 g/kg. G0 and G01 were control groups, groups 1 or 2 were induced and groups 3 and 4 were without induced hyperuricemia. Group 1 (induced hyperuricemia) and Group 3 (without induction) were given the extract of fermented corn silk tea and group 2 and 4 were given the corn silk powder in feed. In the hyperuricemia-induced group, the mean value of uric acid, creatinine, Alanine transaminase, and Aspartate transaminase showed a significant decrease for those who were treated with fermented corn silk tea. Dried corn silk powder showed mixed results of the mean value of uric acid, creatinine, Alanine transaminase, and Aspartate transaminase. Fermented corn silk had the best effect in reducing the raised serum uric acid. The results manifested a remarkable (p<0.05) decrease in serum uric acid, creatinine, Alanine transaminase, and Aspartate transaminase levels. The findings suggest that using fermented corn silk could be an effective strategy to alleviate hyperuricemia in the population predisposed to the development of gout and kidney stones in later stages and can lower the aggregated levels of liver cell injury.

References

[1]Abdallah, M., Ali, M., & Kelany, M. (2016). Antioxidant and antiapoptic effects of combined sidr honey and nigella sativa oil against paracetamol-induced hepato-nephrotoxicity in rats. Zagazig University Medical Journal, 22(1), 1-12. https://doi.org/10.21608/zumj.2016.4588

[2]Amjad, A., Rizwan, B., & Jabeen, S. (2022). The Effect of Methanolic Extract of Corn Silk in Gentamicin Induced Acute Renal Injury in Rats Model. Pakistan BioMedical Journal, 5(1), 308-312. https://doi.org/10.54393/pbmj.v5i1.259

[3]Antimicrobial Residues and Food of Animal Origin. (2023). International Journal of Agriculture and Biosciences, 2, 1-7. https://doi.org/10.47278/book.oht/2023.34

[4]Arthropod Allergy and Public Health. (2021). International Journal of Veterinary Science, Chapter 1, 19-35. https://doi.org/10.47278/book.vpph/2021.003

[5]Aukkanit, N., Kemngoen, T., & Ponharn, N. (2015). Utilization of Corn Silk in Low Fat Meatballs and Its Characteristics. Procedia - Social and Behavioral Sciences, 197, 1403-1410. https://doi.org/10.1016/j.sbspro.2015.07.086

[6]Dietary Toxicity of Heavy Metals; One Health Perspective. (2023). International Journal of Agriculture and Biosciences, 2, 147-152. https://doi.org/10.47278/book.oht/2023.54

[7]El Kewawy, H. (2018). Evaluation of the Efficacy of Corn Silk and Vitamin D on Hyperlipidemia and Obesity in Experimental Rats. Journal of Food and Dairy Sciences, 2018, 169-175. https://doi.org/10.21608/jfds.2018.77775

[8]Fanoush, A., El-Hady, S., El-Wardany, I., & Ali, N. (2018). Effect of egyptian corn silk powder supplementation to diet on some blood parameters, live body weight and liver histology of broiler chickens fed slaughter-houses by-product. Arab Universities Journal of Agricultural Sciences, 26(1), 233-242. https://doi.org/10.21608/ajs.2018.13916

[9]Farsi, D. A., Harris, C. S., Reid, L., Bennett, S. A. L., Haddad, P. S., Martineau, L. C., & Arnason, J. T. (2008). Inhibition of non-enzymatic glycation by silk extracts from a Mexican land race and modern inbred lines of maize ( Zea mays ). Phytotherapy Research, 22(1), 108-112. https://doi.org/10.1002/ptr.2275

[10]Gohari, S., & Mahdy, S. (2018). The roles of Arabic Gum and Corn silk extracts to avoid hepato-nephro toxicity of Gentamicin in rats. African Journal of Biological Sciences, 14(2), 63-78. https://doi.org/10.21608/ajbs.2018.205551

[11]Haslina, & Wahjuningsih, S. B. (2020). Effect of corn silk powder extracts using in vivo to lipid profile and liver fat. IOP Conference Series: Earth and Environmental Science, 443(1), 012010. https://doi.org/10.1088/1755-1315/443/1/012010

[12]Ho, T.-Y., Li, C.-C., Lo, H.-Y., Chen, F.-Y., & Hsiang, C.-Y. (2017). Corn Silk Extract and Its Bioactive Peptide Ameliorated Lipopolysaccharide-Induced Inflammation in Mice via the Nuclear Factor-κB Signaling Pathway. Journal of Agricultural and Food Chemistry, 65(4), 759-768. https://doi.org/10.1021/acs.jafc.6b03327

[13]Jhang, J.-J., Ong, J.-W., Lu, C.-C., Hsu, C.-L., Lin, J.-H., Liao, J.-W., & Yen, G.-C. (2016). Hypouricemic effects of Mesona procumbens Hemsl. through modulating xanthine oxidase activity in vitro and in vivo. Food & Function, 7(10), 4239-4246. https://doi.org/10.1039/C6FO00822D

[14]Li, Z., Li, S., Hu, L., Li, F., Cheung, A. C., Shao, W., Que, Y., Leung, G. P., & Yang, C. (2017). Mechanisms underlying action of xinmailong injection, a traditional chinese medicine in cardiac function improvement. African Journal of Traditional, Complementary and Alternative Medicines, 14(2), 241-252. https://doi.org/10.21010/ajtcam.v14i2.26

[15]Liu, J., Wang, C., Wang, Z., Zhang, C., Lu, S., & Liu, J. (2011). The antioxidant and free-radical scavenging activities of extract and fractions from corn silk (Zea mays L.) and related flavone glycosides. Food Chemistry, 126(1), 261-269. https://doi.org/10.1016/j.foodchem.2010.11.014

[16]Naeem, M. (2022). Protective effect of Corn silk (Zea mays L.) on kidney and liver functions of rats. Bulletin of the National Nutrition Institute of the Arab Republic of Egypt, 60(2), 122-153. https://doi.org/10.21608/bnni.2022.273591

[17]Orr, S., & Bridges, C. (2017). Chronic Kidney Disease and Exposure to Nephrotoxic Metals. International Journal of Molecular Sciences, 18(5), 1039. https://doi.org/10.3390/ijms18051039

[18]Rahman, N. A., & Wan Rosli, W. I. (2014). Nutritional compositions and antioxidative capacity of the silkRahman, N. A., & Wan Rosli, W. I. (2014). Nutritional compositions and antioxidative capacity of the silk obtained from immature and mature corn. Journal of King Saud University - Science, 26(. Journal of King Saud University - Science, 26(2), 119-127.https://doi.org/10.1016/j.jksus.2013.11.002

[19]Ramadani, A. P., Tamhid, H. A., Sadrina, T. L., Jasno, J., & Mustafidah, M. (2020). Hepatoprotective Effect of Corn Silk Infusion in Male Wistar Rats. EKSAKTA: Journal of Sciences and Data Analysis, 51-55. https://doi.org/10.20885/EKSAKTA.vol1.iss1.art8

[20]Redondo-Cuenca, A., Villanueva-Suárez, M. J., & Mateos-Aparicio, I. (2008). Soybean seeds and its by-product okara as sources of dietary fibre. Measurement by AOAC and Englyst methods. Food Chemistry, 108(3), 1099-1105. https://doi.org/10.1016/j.foodchem.2007.11.061

[21]Shi, S., Li, S., Li, W., & Xu, H. (2019). Corn Silk Tea for Hypertension: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Evidence-Based Complementary and Alternative Medicine, 2019, 1-7. https://doi.org/10.1155/2019/2915498

[22]Singh, J., Inbaraj, B. S., Kaur, S., Rasane, P., & Nanda, V. (2022). Phytochemical Analysis and Characterization of Corn Silk (Zea mays, G5417). Agronomy, 12(4), 777. https://doi.org/10.3390/agronomy12040777

[23]Tanideh, N., Zarifi, F., Rafiee, S., Khastkhodaei, M., Koohi Hosseinabadi, O., Tarkesh, F., Kherad, Z., Mojahed Taghi, M., Kamali, M., Shekarkhar, G., Jahromi, M., & Zarifi, F. (2018). Effect of Methanolic Extract of Corn Silk on Cisplatin-Induced Nephrotoxicity in Rats. Galen Medical Journal, 7, e1258. https://doi.org/10.31661/gmj.v7i0.1258

[24]Thirugnanasampandan, R., Ramya, G., Bhuvaneswari, G., Aravindh, S., Vaishnavi, S., & Gogulramnath, M. (2017). Preliminary phytochemical analysis and evaluation of antioxidant, cytotoxic and inhibition of lipopolysaccaride - induced NOS (iNOS) expression in BALB/c mice liver by Ziziphus oenoplia Mill. fruit. Journal of Complementary and Integrative Medicine, 14(2). https://doi.org/10.1515/jcim-2016-0009

[25]Wang, X., Yuan, L., Bao, Z., Fu, B., Jiang, P., Ma, T., & Lin, S. (2021). Screening of uric acid-lowering active components of corn silk polysaccharide and its targeted improvement on renal excretory dysfunction in hyperuricemia mice. Journal of Functional Foods, 86, 104698. https://doi.org/10.1016/j.jff.2021.104698

[26]Wans, E. M., Ahmed, M. M., Mousa, A. A., Tahoun, E. A., & Orabi, S. H. (2021). Ameliorative effects of corn silk extract on acetaminophen-induced renal toxicity in rats. Environmental Science and Pollution Research, 28(2), 1762-1774. https://doi.org/10.1007/s11356-020-10588-4

Therapeutic Effects of Fermented and Dried Corn Silk (Zea mays L.) on Induced Hyperuricemia and Hepatic Cell Injury in Wrister Rats

Authors

DOI:

Keywords:

Abstract

References

Downloads

Published

Issue

Section

License